UCSF

Chronic kidney disease (CKD) is characterized by a progressive decline in kidney function. Evidence demonstrating an association between CKD and periodontitis has been increasing. The aim of this study is to investigate the changes in the microbial profile of dentally underserved CKD patients after non-surgical treatment combined with locally delivered minocycline. 42 patients were divided into a periodontal intensive treatment group and a rescue treatment group. In the periodontal intervention group, patients were treated with scaling and root planing with locally delivered minocycline at sites with pocket depths of 5 mm or more. The control group was treated with scaling and root planing with minocycline administration at the conclusion of the study. Subgingival plaque samples were analyzed at the species-level and the percent frequencies of target taxa found in each sample was further analyzed statistically. When divided into the red complex, orange complex, and newly identified pathogens group, the intensive treatment group showed statistically significant decreases in the levels of all three of these groups. In the control group, the orange complex showed a slight, but non-significant decrease in levels while the red complex and group of newly identified pathogens showed a non-significant increase. At the species level, the intensive treatment group showed statistically significant reductions in a greater number of species than the control group. An intensive periodontal treatment consisting of locally delivered minocycline combined with SRP has a significant benefit in decreasing the oral microbial load of this cohort of dentally underserved CKD patients.