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Open Access Publications from the University of California

Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs

  • Author(s): Kampmann, Martin
  • Gu, S
  • Zhang, Y
  • Jin, L
  • Huang, Y
  • Zhang, F
  • Bassik, MC
  • Kay, MA
  • et al.

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© The Author(s) 2014.The use of RNA interference is becoming routine in scientific discovery and treatment of human disease. However, its applications are hampered by unwanted effects, particularly off-targeting through miRNA-like pathways. Recent studies

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