Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex
- Author(s): Stjepanovic, G
- Baskaran, S
- Lin, MG
- Hurley, JH
- et al.
Published Web Locationhttps://doi.org/10.1080/23723556.2017.1367873
© 2017, © 2017 Taylor & Francis Group, LLC. The class III PI 3-kinase, VPS34 forms distinct complexes essential for cargo sorting and membrane trafficking in endocytosis as well as for autophagosome nucleation and maturation. We used integrative structural biology approach to provide insights into the conformational dynamics of the complex and mechanisms that regulate VPS34 activity at the membrane.
Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.