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Finding a better drug for epilepsy: antiinflammatory targets.

  • Author(s): Dedeurwaerdere, Stefanie
  • Friedman, Alon
  • Fabene, Paolo F
  • Mazarati, Andrèy
  • Murashima, Yoshiya L
  • Vezzani, Annamaria
  • Baram, Tallie Z
  • et al.
Abstract

This monograph summarizes one of the sessions of the XI Workshop on Neurobiology of Epilepsy (WONOEP), and provides a critical review of the current state of the field. Speakers and discussants focused on several broad topics: (1) the coexistence of inflammatory processes encompassing several distinct signal-transduction pathways with the epileptogenic process; (2) evidence for the contribution of specific inflammatory molecules and processes to the onset and progression of epilepsy, as well as to epilepsy-related morbidities including depression; (3) the complexity and intricate cross-talk of the pathways involved in inflammation, and the discrete, often opposite roles of a given mediator in neurons versus other cell types. These complexities highlight the challenges confronting the field as it aims to define inflammatory molecules as promising targets for epilepsy prevention and treatment.

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