RASSF4: Regulator of plasma membrane PI(4,5)P2.
- Author(s): Dickson, Eamonn J
- et al.
Published Web Locationhttps://doi.org/10.1083/jcb.201706042
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane-cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201606047) demonstrate that RAS association domain family 4 (RASSF4) positively influences PI(4,5)P2 synthesis through ARF6-dependent regulation of PIP5K.