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Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

  • Author(s): Papa, Feroz
  • Oakes, Scott
  • Wang, L
  • Perera, BGK
  • Hari, SB
  • Bhhatarai, B
  • Backes, BJ
  • Seeliger, MA
  • Schürer, SC
  • Oakes, SA
  • Papa, FR
  • Maly, DJ
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3508346?pdf=render
No data is associated with this publication.
Abstract

Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase/endoRNase (RNase) IRE1α. IRE1α oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus triggering the

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