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Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis.

  • Author(s): Faber, Franziska;
  • Thiennimitr, Parameth;
  • Spiga, Luisella;
  • Byndloss, Mariana X;
  • Litvak, Yael;
  • Lawhon, Sara;
  • Andrews-Polymenis, Helene L;
  • Winter, Sebastian E;
  • Bäumler, Andreas J
  • et al.
Abstract

Intestinal inflammation caused by Salmonella enterica serovar Typhimurium increases the availability of electron acceptors that fuel a respiratory growth of the pathogen in the intestinal lumen. Here we show that one of the carbon sources driving this respiratory expansion in the mouse model is 1,2-propanediol, a microbial fermentation product. 1,2-propanediol utilization required intestinal inflammation induced by virulence factors of the pathogen. S. Typhimurium used both aerobic and anaerobic respiration to consume 1,2-propanediol and expand in the murine large intestine. 1,2-propanediol-utilization did not confer a benefit in germ-free mice, but the pdu genes conferred a fitness advantage upon S. Typhimurium in mice mono-associated with Bacteroides fragilis or Bacteroides thetaiotaomicron. Collectively, our data suggest that intestinal inflammation enables S. Typhimurium to sidestep nutritional competition by respiring a microbiota-derived fermentation product.

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