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Background parenchymal enhancement in the contralateral normal breast of patients undergoing neoadjuvant chemotherapy measured by DCE-MRI

  • Author(s): Chen, JH
  • Yu, H
  • Lin, M
  • Mehta, RS
  • Su, MY
  • et al.
Abstract

The purpose of this study was to analyze background parenchymal enhancement (BPE) in the contralateral normal breast of cancer patients during the course of neoadjuvant chemotherapy (NAC).Forty-five subjects were analyzed. Each patient had three MRIs, one baseline (B/L) and two follow-up (F/U) studies. The fibroglandular tissue in the contralateral normal breast was segmented using a computer-assisted algorithm. Based on the segmented fibroglandular tissue, BPE was calculated. BPE measured in baseline (B/L) and follow-up (F/U) MR studies were compared. The baseline BPE was also correlated with age and compared between pre/peri-menopausal (<. 55. years old) and post-menopausal women (≥. 55. years old). The pre-treatment BPE measured in B/L MRI was significantly higher in women <. 55. years old than in women ≥. 55. years old (20.1%. ±. 7.4% vs. 12.1%. ±. 5.1%, p≤. 0.01). A trend of negative correlation between BPE and age was noted (r=0.29). In women <. 55. years old, BPE at F/U-1 (18.8%. ±. 6.9%) was decreased compared to B/L, and was further decreased in F/U-2 (13.3%. ±. 5.7%) which was significant compared to B/L and F/U-1. In women ≥. 55. years old, no significant difference was noted in any paired comparison among B/L, F/U-1 and F/U-2 MRI. A higher baseline BPE was associated with a greater reduction of BPE in F/U-2 MRI (r=0.73). Our study showed that younger women tended to have higher BPE than older women. BPE was significantly decreased in F/U-2 MRI after NAC in women <. 55. years old. The reduction in BPE was most likely due to the ovarian ablation induced by chemotherapeutic agents. © 2013 Elsevier Inc.

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