Skip to main content
eScholarship
Open Access Publications from the University of California

Toward clinical genomics in everyday medicine: perspectives and recommendations.

  • Author(s): Delaney, Susan K
  • Hultner, Michael L
  • Jacob, Howard J
  • Ledbetter, David H
  • McCarthy, Jeanette J
  • Ball, Michael
  • Beckman, Kenneth B
  • Belmont, John W
  • Bloss, Cinnamon S
  • Christman, Michael F
  • Cosgrove, Andy
  • Damiani, Stephen A
  • Danis, Timothy
  • Delledonne, Massimo
  • Dougherty, Michael J
  • Dudley, Joel T
  • Faucett, W Andrew
  • Friedman, Jennifer R
  • Haase, David H
  • Hays, Tom S
  • Heilsberg, Stu
  • Huber, Jeff
  • Kaminsky, Leah
  • Ledbetter, Nikki
  • Lee, Warren H
  • Levin, Elissa
  • Libiger, Ondrej
  • Linderman, Michael
  • Love, Richard L
  • Magnus, David C
  • Martland, AnneMarie
  • McClure, Susan L
  • Megill, Scott E
  • Messier, Helen
  • Nussbaum, Robert L
  • Palaniappan, Latha
  • Patay, Bradley A
  • Popovich, Bradley W
  • Quackenbush, John
  • Savant, Mark J
  • Su, Michael M
  • Terry, Sharon F
  • Tucker, Steven
  • Wong, William T
  • Green, Robert C
  • et al.
Abstract

Precision or personalized medicine through clinical genome and exome sequencing has been described by some as a revolution that could transform healthcare delivery, yet it is currently used in only a small fraction of patients, principally for the diagnosis of suspected Mendelian conditions and for targeting cancer treatments. Given the burden of illness in our society, it is of interest to ask how clinical genome and exome sequencing can be constructively integrated more broadly into the routine practice of medicine for the betterment of public health. In November 2014, 46 experts from academia, industry, policy and patient advocacy gathered in a conference sponsored by Illumina, Inc. to discuss this question, share viewpoints and propose recommendations. This perspective summarizes that work and identifies some of the obstacles and opportunities that must be considered in translating advances in genomics more widely into the practice of medicine.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View