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Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

Published Web Location

https://doi.org/10.1038/nsmb.1904
Abstract

BRCA2 is a tumor suppressor that interacts with RAD51 and functions in homologous recombination, but understanding its precise functions has been hampered by difficulties in purifying such a large protein. Now purified full-length human BRCA2 is shown to bind ∼6 molecules of RAD51 and to promote RAD51 binding to RPA-covered ssDNA in a manner stimulated by DSS1.

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