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The complete genome sequence of Haloferax volcanii DS2, a model archaeon.

  • Author(s): Hartman, Amber L;
  • Norais, Cédric;
  • Badger, Jonathan H;
  • Delmas, Stéphane;
  • Haldenby, Sam;
  • Madupu, Ramana;
  • Robinson, Jeffrey;
  • Khouri, Hoda;
  • Ren, Qinghu;
  • Lowe, Todd M;
  • Maupin-Furlow, Julie;
  • Pohlschroder, Mecky;
  • Daniels, Charles;
  • Pfeiffer, Friedhelm;
  • Allers, Thorsten;
  • Eisen, Jonathan A
  • et al.
Abstract

Background

Haloferax volcanii is an easily culturable moderate halophile that grows on simple defined media, is readily transformable, and has a relatively stable genome. This, in combination with its biochemical and genetic tractability, has made Hfx. volcanii a key model organism, not only for the study of halophilicity, but also for archaeal biology in general.

Methodology/principal findings

We report here the sequencing and analysis of the genome of Hfx. volcanii DS2, the type strain of this species. The genome contains a main 2.848 Mb chromosome, three smaller chromosomes pHV1, 3, 4 (85, 438, 636 kb, respectively) and the pHV2 plasmid (6.4 kb).

Conclusions/significance

The completed genome sequence, presented here, provides an invaluable tool for further in vivo and in vitro studies of Hfx. volcanii.

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