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Understanding the Role of the Salmonella Typhi Vi Capsular Polysaccharide in Neutrophil and Macrophage Phagocytosis
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Abstract
Salmonella Typhi is the causative agent of typhoid fever, which is a lifethreatening, systemic disease, with an estimated global disease burden of 21.6 million cases annually, resulting in about 220,000 deaths. Due to the absence of convenient animals models to study S. Typhi and other typhoidal Salmonella serovars, our understanding of typhoid fever pathogenesis is still incomplete.
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