Skip to main content
eScholarship
Open Access Publications from the University of California

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Clinical testing of a photoacoustic probe for port wine stain depth determination.

  • Author(s): Viator, John A
  • Au, Gigi
  • Paltauf, Guenther
  • Jacques, Steven L
  • Prahl, Scott A
  • Ren, Hongwu
  • Chen, Zhongping
  • Nelson, J Stuart
  • et al.

Published Web Location

https://doi.org/10.1002/lsm.10015Creative Commons 'BY' version 4.0 license
Abstract

Background and objective

Successful laser treatment of port wine stain (PWS) birthmarks requires knowledge of lesion geometry. Laser parameters, such as pulse duration, wavelength, and radiant exposure, and other treatment parameters, such as cryogen spurt duration, need to be optimized according to epidermal melanin content and lesion depth. We designed, constructed, and clinically tested a photoacoustic probe for PWS depth determination.

Study design/materials and methods

Energy from a frequency-doubled, Nd:YAG laser (lambda=532 nm, tau(p)=4 nanoseconds) was coupled into two 1,500 mum optical fibers fitted into an acrylic handpiece containing a piezoelectric acoustic detector. Laser light induced photoacoustic waves in tissue phantoms and a patient's PWS. The photoacoustic propagation time was used to calculate the depth of the embedded absorbers and PWS lesion.

Results

Calculated chromophore depths in tissue phantoms were within 10% of the actual depths of the phantoms. PWS depths were calculated as the sum of the epidermal thickness, determined by optical coherence tomography (OCT), and the epidermal-to-PWS thickness, determined photoacoustically. PWS depths were all in the range of 310-570 microm. The experimentally determined PWS depths were within 20% of those measured by optical Doppler tomography (ODT).

Conclusions

PWS lesion depth can be determined by a photoacoustic method that utilizes acoustic propagation time.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View