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Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche
- Chen, James Y;
- Miyanishi, Masanori;
- Wang, Sean K;
- Yamazaki, Satoshi;
- Sinha, Rahul;
- Kao, Kevin S;
- Seita, Jun;
- Sahoo, Debashis;
- Nakauchi, Hiromitsu;
- Weissman, Irving L
Published Web Location
https://doi.org/10.1038/nature16943Abstract
Until recently, complex multi-parameters were required for the isolation and identification of haematopoietic stem cells, complicating study of their biology in situ; here the authors have found that expression of a single gene, Hoxb5, defines haematopoietic stem cells with long-term reconstitution capacity, and that these cells are mainly found in direct contact with endothelial cells.
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