Skip to main content
eScholarship
Open Access Publications from the University of California

Cell type specificity of neurovascular coupling in cerebral cortex.

  • Author(s): Uhlirova, Hana
  • Kılıç, Kıvılcım
  • Tian, Peifang
  • Thunemann, Martin
  • Desjardins, Michèle
  • Saisan, Payam A
  • Sakadžić, Sava
  • Ness, Torbjørn V
  • Mateo, Celine
  • Cheng, Qun
  • Weldy, Kimberly L
  • Razoux, Florence
  • Vandenberghe, Matthieu
  • Cremonesi, Jonathan A
  • Ferri, Christopher Gl
  • Nizar, Krystal
  • Sridhar, Vishnu B
  • Steed, Tyler C
  • Abashin, Maxim
  • Fainman, Yeshaiahu
  • Masliah, Eliezer
  • Djurovic, Srdjan
  • Andreassen, Ole A
  • Silva, Gabriel A
  • Boas, David A
  • Kleinfeld, David
  • Buxton, Richard B
  • Einevoll, Gaute T
  • Dale, Anders M
  • Devor, Anna
  • et al.
Abstract

Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View