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Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss
- Gross, Andrew M;
- Orosco, Ryan K;
- Shen, John P;
- Egloff, Ann Marie;
- Carter, Hannah;
- Hofree, Matan;
- Choueiri, Michel;
- Coffey, Charles S;
- Lippman, Scott M;
- Hayes, D Neil;
- Cohen, Ezra E;
- Grandis, Jennifer R;
- Nguyen, Quyen T;
- Ideker, Trey
Published Web Location
https://doi.org/10.1038/ng.3051Abstract
Trey Ideker and colleagues report a comprehensive genome-wide analysis of head and neck squamous cell carcinoma, reporting that TP53 mutations are frequently accompanied by loss of chromosome 3p. Their data indicate that the combination of these two events has a stronger negative effect on survival rate than either event alone.
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