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Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study.
- Author(s): Petersen, Melissa E
- Zhang, Fan
- Schupf, Nicole
- Krinsky-McHale, Sharon J
- Hall, James
- Mapstone, Mark
- Cheema, Amrita
- Silverman, Wayne
- Lott, Ira
- Rafii, Michael S
- Handen, Benjamin
- Klunk, William
- Head, Elizabeth
- Christian, Brad
- Foroud, Tatiana
- Lai, Florence
- Rosas, H Diana
- Zaman, Shahid
- Ances, Beau M
- Wang, Mei-Cheng
- Tycko, Benjamin
- Lee, Joseph H
- O'Bryant, Sid
- Alzheimer's Biomarker Consortium – Down Syndrome (ABC‐DS)
- et al.
Published Web Location
https://doi.org/10.1002/dad2.12039Abstract
Introduction:Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) and Alzheimer's disease (DS-AD) from those cognitively stable (CS). Methods:Data were analyzed on n = 305 (n = 225 CS; n = 44 MCI-DS; n = 36 DS-AD) enrolled in the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS). Results:Distinguishing MCI-DS from CS, the serum profile produced an area under the curve (AUC) = 0.95 (sensitivity [SN] = 0.91; specificity [SP] = 0.99) and an AUC = 0.98 (SN = 0.96; SP = 0.97) for plasma when using an optimized cut-off score. Distinguishing DS-AD from CS, the serum profile produced an AUC = 0.93 (SN = 0.81; SP = 0.99) and an AUC = 0.95 (SN = 0.86; SP = 1.0) for plasma when using an optimized cut-off score. AUC remained unchanged to slightly improved when age and sex were included. Eotaxin3, interleukin (IL)-10, C-reactive protein, IL-18, serum amyloid A , and FABP3 correlated fractions at r2 > = 0.90. Discussion:Proteomic profiles showed excellent detection accuracy for MCI-DS and DS-AD.
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