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Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study.

  • Author(s): Petersen, Melissa E
  • Zhang, Fan
  • Schupf, Nicole
  • Krinsky-McHale, Sharon J
  • Hall, James
  • Mapstone, Mark
  • Cheema, Amrita
  • Silverman, Wayne
  • Lott, Ira
  • Rafii, Michael S
  • Handen, Benjamin
  • Klunk, William
  • Head, Elizabeth
  • Christian, Brad
  • Foroud, Tatiana
  • Lai, Florence
  • Rosas, H Diana
  • Zaman, Shahid
  • Ances, Beau M
  • Wang, Mei-Cheng
  • Tycko, Benjamin
  • Lee, Joseph H
  • O'Bryant, Sid
  • Alzheimer's Biomarker Consortium – Down Syndrome (ABC‐DS)
  • et al.
Abstract

Introduction:Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) and Alzheimer's disease (DS-AD) from those cognitively stable (CS). Methods:Data were analyzed on n = 305 (n = 225 CS; n = 44 MCI-DS; n = 36 DS-AD) enrolled in the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS). Results:Distinguishing MCI-DS from CS, the serum profile produced an area under the curve (AUC) = 0.95 (sensitivity [SN] = 0.91; specificity [SP] = 0.99) and an AUC = 0.98 (SN = 0.96; SP = 0.97) for plasma when using an optimized cut-off score. Distinguishing DS-AD from CS, the serum profile produced an AUC = 0.93 (SN = 0.81; SP = 0.99) and an AUC = 0.95 (SN = 0.86; SP = 1.0) for plasma when using an optimized cut-off score. AUC remained unchanged to slightly improved when age and sex were included. Eotaxin3, interleukin (IL)-10, C-reactive protein, IL-18, serum amyloid A , and FABP3 correlated fractions at r2 > = 0.90. Discussion:Proteomic profiles showed excellent detection accuracy for MCI-DS and DS-AD.

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