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Parameterization of Acyclic Diaminocarbene Ligands Applied to a Gold(I)-Catalyzed Enantioselective Tandem Rearrangement/Cyclization.
- Author(s): Niemeyer, Zachary L
- Pindi, Suresh
- Khrakovsky, Dimitri A
- Kuzniewski, Christian N
- Hong, Cynthia M
- Joyce, Leo A
- Sigman, Matthew S
- Toste, F Dean
- et al.
Published Web Location
https://doi.org/10.1021/jacs.7b08791Abstract
Computed descriptors for acyclic diaminocarbene ligands are developed in the context of a gold catalyzed enantioselective tandem [3,3]-sigmatropic rearrangement-[2+2]-cyclization. Surrogate structures enable the rapid identification of parameters that reveal mechanistic characteristics. The observed selectivity trends are validated in a robust multivariate analysis facilitating the development of a highly enantioselective process.
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