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Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome

  • Author(s): Gambús, PL
  • Trocóniz, IF
  • Feng, X
  • Gimenez-Milá, M
  • Mellado, R
  • Degos, V
  • Vacas, S
  • Maze, M
  • et al.

Published Web Location

http://www.sciencedirect.com/science/article/pii/S0889159115002391?via=ihub
No data is associated with this publication.
Abstract

© 2015 Elsevier Inc.. Introduction: The relationship between persistent postoperative cognitive decline and the more common acute variety remains unknown; using data acquired in preclinical studies of postoperative cognitive decline we attempted to characterize this relationship. Methods: Low capacity runner (LCR) rats, which have all the features of the metabolic syndrome, were compared postoperatively with high capacity runner (HCR) rats for memory, assessed by trace fear conditioning (TFC) on the 7th postoperative day, and learning and memory (probe trial [PT]) assessed by the Morris water-maze (MWM) at 3 months postoperatively. Rate of learning (AL) data from the MWM test, were estimated by non-linear mixed effects modeling. The individual rat's TFC result at postoperative day (POD) 7 was correlated with its ALand PT from the MWM data sets at postoperative day POD 90. Results: A single exponential decay model best described ALin the MWM with LCR and surgery (LCR-SURG) being the only significant covariates; first order ALrate constant was 0.07 s-1in LCR-SURG and 0.16 s-1in the remaining groups (p < 0.05). TFC was significantly correlated with both AL(R = 0.74; p < 0.0001) and PT (R = 0.49; p < 0.01). Conclusion: Severity of memory decline at 1 week after surgery presaged long-lasting deteriorations in learning and memory.

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