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Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome
Published Web Location
http://www.sciencedirect.com/science/article/pii/S0889159115002391?via=ihubNo data is associated with this publication.
Abstract
Introduction
The relationship between persistent postoperative cognitive decline and the more common acute variety remains unknown; using data acquired in preclinical studies of postoperative cognitive decline we attempted to characterize this relationship.Methods
Low capacity runner (LCR) rats, which have all the features of the metabolic syndrome, were compared postoperatively with high capacity runner (HCR) rats for memory, assessed by trace fear conditioning (TFC) on the 7th postoperative day, and learning and memory (probe trial [PT]) assessed by the Morris water-maze (MWM) at 3 months postoperatively. Rate of learning (AL) data from the MWM test, were estimated by non-linear mixed effects modeling. The individual rat's TFC result at postoperative day (POD) 7 was correlated with its AL and PT from the MWM data sets at postoperative day POD 90.Results
A single exponential decay model best described AL in the MWM with LCR and surgery (LCR-SURG) being the only significant covariates; first order AL rate constant was 0.07 s(-1) in LCR-SURG and 0.16s(-1) in the remaining groups (p<0.05). TFC was significantly correlated with both AL (R=0.74; p<0.0001) and PT (R=0.49; p<0.01).Conclusion
Severity of memory decline at 1 week after surgery presaged long-lasting deteriorations in learning and memory.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.