Skip to main content
Download PDF
- Main
Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases
- Allen, Mariet;
- Wang, Xue;
- Burgess, Jeremy D;
- Watzlawik, Jens;
- Serie, Daniel J;
- Younkin, Curtis S;
- Nguyen, Thuy;
- Malphrus, Kimberly G;
- Lincoln, Sarah;
- Carrasquillo, Minerva M;
- Ho, Charlotte;
- Chakrabarty, Paramita;
- Strickland, Samantha;
- Murray, Melissa E;
- Swarup, Vivek;
- Geschwind, Daniel H;
- Seyfried, Nicholas T;
- Dammer, Eric B;
- Lah, James J;
- Levey, Allan I;
- Golde, Todd E;
- Funk, Cory;
- Li, Hongdong;
- Price, Nathan D;
- Petersen, Ronald C;
- Graff‐Radford, Neill R;
- Younkin, Steven G;
- Dickson, Dennis W;
- Crook, Julia R;
- Asmann, Yan W;
- Ertekin‐Taner, Nilüfer
Published Web Location
https://doi.org/10.1016/j.jalz.2017.09.012Abstract
Introduction
Comparative transcriptome analyses in Alzheimer's disease (AD) and other neurodegenerative proteinopathies can uncover both shared and distinct disease pathways.Methods
We analyzed 940 brain transcriptomes including patients with AD, progressive supranuclear palsy (PSP; a primary tauopathy), and control subjects.Results
We identified transcriptional coexpression networks implicated in myelination, which were lower in PSP temporal cortex (TCX) compared with AD. Some of these associations were retained even after adjustments for brain cell population changes. These TCX myelination network structures were preserved in cerebellum but they were not differentially expressed in cerebellum between AD and PSP. Myelination networks were downregulated in both AD and PSP, when compared with control TCX samples.Discussion
Downregulation of myelination networks may underlie both PSP and AD pathophysiology, but may be more pronounced in PSP. These data also highlight conservation of transcriptional networks across brain regions and the influence of cell type changes on these networks.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
For improved accessibility of PDF content, download the file to your device.
Enter the password to open this PDF file:
File name:
-
File size:
-
Title:
-
Author:
-
Subject:
-
Keywords:
-
Creation Date:
-
Modification Date:
-
Creator:
-
PDF Producer:
-
PDF Version:
-
Page Count:
-
Page Size:
-
Fast Web View:
-
Preparing document for printing…
0%