UC Irvine

This thesis provides a comprehensive summary of my PhD studies, investigating the potential application of diverse laser technologies in treating two prevalent eye conditions: glaucoma and meibomian gland dysfunction (MGD). Glaucoma is the leading cause of irreversible blindness affecting approximately 80 million individuals worldwide. We explored the use of femtosecond lasers for precise photodisruption of the trabecular meshwork, a vital surgical region within the human eye. The dissertation begins with an examination of the optimization of pulse energy levels in femtosecond laser trabeculoplasty (FLT), enhancing its effectiveness as a treatment for glaucoma. Additionally, the temperature variations observed during FLT surgeries and evaluation of potential collateral damage in human cadaver eyes have been investigated. To enhance targeting precision in surgical interventions, we have developed a micron-scale spectral domain optical coherence tomography system tailored for iridocorneal angle imaging. The thesis highlights the use of short-time Fourier transform to compensate for dispersion, a crucial step in achieving superior axial resolution. Moreover, advanced imaging processing techniques and hardware implementations are presented to demonstrate the comprehensive and detailed visualization of the surgical area within the angle. In the second part of the dissertation, attention is shifted towards our research endeavors focused on addressing MGD. Firstly, methods leveraging numerical modeling and analytical derivations are discussed, shedding light on alternative mechanisms underlying the development of obstructive MGD. Additionally, an innovative treatment approach called selective photothermal ablation (SPA) is introduced, showcasing its potential in selectively targeting the meibomian glands while preserving the overlying conjunctival integrity.