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A genetically encoded tool for manipulation of NADP+/NADPH in living cells

Published Web Location

https://doi.org/10.1038/nchembio.2454
Abstract

Structure-guided engineering of an NADH oxidase switches its cofactor preference, thus yielding an NADPH oxidase that can be used to tune the cellular NADP+/NADPH ratio and to examine the links between mitochondrial NADH and NADPH pools.

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