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The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR
- Nguyen, Trang TT;
- Kläsener, Kathrin;
- Zürn, Christa;
- Castillo, Patricia A;
- Brust-Mascher, Ingrid;
- Imai, Denise M;
- Bevins, Charles L;
- Reardon, Colin;
- Reth, Michael;
- Baumgarth, Nicole
Published Web Location
https://doi.org/10.1038/ni.3677Abstract
FcμR serves as a receptor for soluble IgM. Baumgarth and colleagues show that intracellular FcμR constrains the surface expression of IgM. Lack of FcμR alters B cell populations and enhances autoantibody production. FcμR thereby serves as a critical regulator of B cell homeostasis.
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