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Improving the assessment of vancomycin-resistant enterococci by routine screening.

  • Author(s): Huang, Susan S
  • Rifas-Shiman, Sheryl L
  • Pottinger, Jean M
  • Herwaldt, Loreen A
  • Zembower, Teresa R
  • Noskin, Gary A
  • Cosgrove, Sara E
  • Perl, Trish M
  • Curtis, Amy B
  • Tokars, Jerome L
  • Diekema, Daniel J
  • Jernigan, John A
  • Hinrichsen, Virginia L
  • Yokoe, Deborah S
  • Platt, Richard
  • Centers for Disease Control and Prevention Epicenters Program
  • et al.

Published Web Location

https://doi.org/10.1086/510624Creative Commons 'BY' version 4.0 license
Abstract

BACKGROUND: As infection with vancomycin-resistant enterococci (VRE) increases in hospitals, knowledge about VRE reservoirs and improved accuracy of epidemiologic measures are needed. Many assessments underestimate incidence by including prevalent carriers in at-risk populations. Routine surveillance cultures can substantially improve prevalence and incidence estimates, and assessing the range of improvement across diverse units is important. METHODS: We performed a retrospective cohort study using accurate at-risk populations to evaluate the range of benefit of admission and weekly surveillance cultures in detecting unrecognized VRE in 14 patient-care units. RESULTS: We assessed 165 unit-months. The admission prevalence of VRE was 2.2%-27.2%, with admission surveillance providing 2.2-17-fold increased detection. Medical units were significantly more likely to admit VRE carriers than were surgical units. Monthly incidence was 0.8%-9.7%, with weekly surveillance providing 3.3-15.4-fold increased detection. The common practice of reporting incidence using the total number of patients, rather than patients at risk, underestimated incidence by one-third. Overall, routine surveillance prevented the misclassification of 43.0% (unit range, 0%-85.7%) of "incident" carriers on the basis of clinical cultures alone and increased VRE precaution days by 2.4-fold (unit range, 2.0-2.6-fold). CONCLUSIONS: Routine surveillance markedly increases the detection of VRE, despite variability across patient-care units. Correct denominators prevent the substantial underestimation of incidence.

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