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Viral infections in interferon-gamma receptor deficiency.

  • Author(s): Dorman, SE
  • Uzel, G
  • Roesler, J
  • Bradley, JS
  • Bastian, J
  • Billman, G
  • King, S
  • Filie, A
  • Schermerhorn, J
  • Holland, SM
  • et al.

Interferon-gamma receptor deficiency is a recently described immunodeficiency that is associated with onset of severe mycobacterial infections in childhood. We describe the occurrence of symptomatic and often severe viral infections in 4 patients with interferon-gamma receptor deficiency and mycobacterial disease. The viral pathogens included herpes viruses, parainfluenza virus type 3, and respiratory syncytial virus. We conclude that patients with interferon-gamma receptor deficiency and mycobacterial disease have increased susceptibility to some viral pathogens.

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