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Viral infections in interferon-gamma receptor deficiency.

  • Author(s): Dorman, SE;
  • Uzel, G;
  • Roesler, J;
  • Bradley, JS;
  • Bastian, J;
  • Billman, G;
  • King, S;
  • Filie, A;
  • Schermerhorn, J;
  • Holland, SM
  • et al.

Interferon-gamma receptor deficiency is a recently described immunodeficiency that is associated with onset of severe mycobacterial infections in childhood. We describe the occurrence of symptomatic and often severe viral infections in 4 patients with interferon-gamma receptor deficiency and mycobacterial disease. The viral pathogens included herpes viruses, parainfluenza virus type 3, and respiratory syncytial virus. We conclude that patients with interferon-gamma receptor deficiency and mycobacterial disease have increased susceptibility to some viral pathogens.

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