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A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab.

  • Author(s): Munster, Pamela
  • Lin, NU
  • Winer, EP
  • Wheatley, D
  • Carey, LA
  • Houston, S
  • Mendelson, D
  • Frakes, L
  • Kelly, S
  • Garcia, AA
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3387495?pdf=render
No data is associated with this publication.
Abstract

Afatinib is an oral, ErbB family blocker, which covalently binds and irreversibly blocks all kinase-competent ErbB family members. This phase II, open-label, single-arm study explored afatinib activity in human epidermal growth factor receptor 2 (HER2)-pos

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