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CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation

  • Author(s): Hebrok, Matthias
  • Goga, Andrei
  • Oakes, Scott
  • Blelloch, Robert
  • Huskey, N
  • Guo, T
  • Evason, K
  • Momcilovic, O
  • Pardo, D
  • Creasman, K
  • Judson, R
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4375943?pdf=render
No data is associated with this publication.
Abstract

Embryonic stem cells (ESCs) have adopted an accelerated cell-cycle program with shortened gap phases and precocious expression of cell-cycle regulatory proteins, including cyclins and cyclin-dependent kinases (CDKs). We examined the effect of CDK inhibitio

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