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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
- Fang, Sungsoon;
- Suh, Jae Myoung;
- Reilly, Shannon M;
- Yu, Elizabeth;
- Osborn, Olivia;
- Lackey, Denise;
- Yoshihara, Eiji;
- Perino, Alessia;
- Jacinto, Sandra;
- Lukasheva, Yelizaveta;
- Atkins, Annette R;
- Khvat, Alexander;
- Schnabl, Bernd;
- Yu, Ruth T;
- Brenner, David A;
- Coulter, Sally;
- Liddle, Christopher;
- Schoonjans, Kristina;
- Olefsky, Jerrold M;
- Saltiel, Alan R;
- Downes, Michael;
- Evans, Ronald M
Published Web Location
https://doi.org/10.1038/nm.3760Abstract
Restriction of FXR agonism to the gut improves obesity and diabetes.
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