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Genotype-dependent efficacy of a Dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas
- McCormick, Frank;
- Shoji, K;
- Oda, K;
- Kashiyama, T;
- Ikeda, Y;
- Nakagawa, S;
- Sone, K;
- Miyamoto, Y;
- Hiraike, H;
- Tanikawa, M;
- Miyasaka, A
Published Web Location
http://europepmc.org/articles/PMC3360787?pdf=renderNo data is associated with this publication.
Abstract
The PI3K (phosphatidylinositol-3-kinase)/mTOR (mammalian target of rapamycin) pathway is frequently activated in endometrial cancer through various PI3K/AKT-activating genetic alterations. We examined the antitumor effect of NVP-BEZ235-a dual PI3K/mTOR inh
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