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One-way membrane trafficking of SOS in receptor-triggered Ras activation
Published Web Location
http://europepmc.org/articles/PMC5016256?pdf=renderNo data is associated with this publication.
Abstract
SOS is a key activator of the small GTPase Ras. In cells, SOS-Ras signaling is thought to be initiated predominantly by membrane recruitment of SOS via the adaptor Grb2 and balanced by rapidly reversible Grb2-SOS binding kinetics. However, SOS has multiple
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