Cognitive Science & Psychology Division, ULAB

While there have been previous studies linking beta-amyloid accumulation in the positive range and cognitive decline, there has yet to be substantial research focusing on the significance of beta-amyloid accumulation in the negative range. The present study aims to replicate the findings of the original paper by Landau et al. 2018 which investigated potential associations between subthreshold levels of beta-amyloid accumulation and decreased executive or memory function. Utilizing data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), longitudinal beta-amyloid accumulation from florbetapir-18 PET scan measurements in cognitively normal individuals and mild cognitively impaired was compared with longitudinal executive and memory function measurements. These findings will provide implications as to whether beta-amyloid accumulation in healthy, cognitively normal individuals may be an earlier indicator of cognitive decline.