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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- Hangauer, Matthew J;
- Viswanathan, Vasanthi S;
- Ryan, Matthew J;
- Bole, Dhruv;
- Eaton, John K;
- Matov, Alexandre;
- Galeas, Jacqueline;
- Dhruv, Harshil D;
- Berens, Michael E;
- Schreiber, Stuart L;
- McCormick, Frank;
- McManus, Michael T
Published Web Location
https://doi.org/10.1038/nature24297Abstract
Cancer persister cells, which survive cytotoxic treatments, are shown to be sensitive to inhibition of the lipid hydroperoxidase GPX4.
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