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Incidence of dementia after age 90 in a multiracial cohort.
- Gilsanz, Paola;
- Corrada, Maria M;
- Kawas, Claudia H;
- Mayeda, Elizabeth Rose;
- Glymour, M Maria;
- Quesenberry, Charles P;
- Lee, Catherine;
- Whitmer, Rachel A
Published Web Location
https://doi.org/10.1016/j.jalz.2018.12.006Abstract
Introduction
Little is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence.Methods
Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ≥90 in 2010. We estimated race/ethnicity-specific age-adjusted dementia incidence rates and implemented Cox proportional hazards models and Fine and Gray competing risk of death models adjusted for demographics and comorbidities in midlife and late-life.Results
Dementia incidence rates (n = 771 cases) were lowest among Asians (89.9/1000 person-years), followed by whites (96.9/1000 person-years), Latinos (105.8/1000 person-years), and blacks (121.5/1000 person-years). Cox regression and competing risk models estimated 28% and 36% higher dementia risk for blacks versus whites adjusting for demographics and comorbidities.Discussion
Patterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.