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Cellular uptake of modified aminoglycosides

Published Web Location

https://doi.org/10.1038/ja.2017.131
Abstract

The uptake of modified amino- and guanidino-glycosides derived from kanamycin, tobramycin and neomycin in native and mutant CHO cells is examined using confocal microscopy and flow cytometry, illustrating the significance of multivalency for mammalian cell internalization of carriers that specifically interact with cell surface heparan sulfate proteoglycans.

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