Cellular uptake of modified aminoglycosides.
- Author(s): Hadidi, Kaivin
- Wexselblatt, Ezequiel
- Esko, Jeffrey D
- Tor, Yitzhak
- et al.
Published Web Locationhttps://doi.org/10.1038/ja.2017.131
The uptake of modified amino- and guanidino-glycosides derived from kanamycin, tobramycin and neomycin in native and mutant CHO cells is examined using confocal microscopy and flow cytometry, illustrating the significance of multivalency for mammalian cell internalization of carriers that specifically interact with cell surface heparan sulfate proteoglycans.The Journal of Antibiotics advance online publication, 1 November 2017; doi:10.1038/ja.2017.131.