Skip to main content
eScholarship
Open Access Publications from the University of California

Long-term outcomes among African-American and white women with breast cancer: What is the impact of comorbidity?

  • Author(s): Izano, M
  • Satariano, WA
  • Tammemagi, MC
  • Ragland, D
  • Moore, DH
  • Allen, E
  • Naeim, A
  • Sehl, ME
  • Hiatt, RA
  • Kerlikowske, K
  • Sofrygin, O
  • Braithwaite, D
  • et al.

Published Web Location

http://www.sciencedirect.com/science/article/pii/S1879406814000393
No data is associated with this publication.
Abstract

Objectives: We examined the association between comorbidity and long-term mortality from breast cancer and other causes among African-American and white women with breast cancer. Methods: A total of 170 African-American and 829 white women aged 40-84 years were followed for up to 28 years with median follow-up of 11.3 years in the Health and Functioning in Women (HFW) study. The impact of the Charlson Comorbidity Score (CCS) in the first few months following breast cancer diagnosis on the risk of mortality from breast cancer and other causes was examined using extended Cox models. Results: Median follow-up was significantly shorter for African-American women than their white counterparts (median 8.5 years vs. 12.3 years). Compared to white women, African-American women had significantly fewer years of education, greater body mass index, were more likely to have functional limitations and later stage at breast cancer diagnosis, and fewer had adequate financial resources (all P < 0.05). Proportionately more African-American women died of breast cancer than white women (37.1% vs. 31.4%, P = 0.15). A positive and statistically significant time-varying effect of the Charlson Comorbidity Score (CCS) on other-cause mortality persisted throughout the first 5 years of follow-up (P < 0.001) but not for its remainder. Conclusions: Higher CCS was associated with increased risk of other-cause mortality, but not breast cancer specific mortality; the association did not differ among African-American and white women. © 2014 Elsevier Inc. All rights reserved.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item