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Functional and Histologic Analysis of a Novel Elastic Biodegradable Patch for CDH Repair

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Abstract

CDH is a congenital defect in the diaphragm causing herniation of abdominal contents and impaired lung growth. PTFE is a synthetic polymer that is the current standard of care for patch repair of CDH. Limitations: stiff, not biodegradable, no growth with the child leading to reherniation and repeated intervention. Polyurethane (PU) is a novel material that is elastic, biodegradable, and biocompatible, allowing for optimized lung mechanics and tissue integration.

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