Skip to main content
Open Access Publications from the University of California

UC Santa Barbara

UC Santa Barbara Electronic Theses and Dissertations bannerUC Santa Barbara

Real-time measurement, analysis, and control in microfluidic systems for personalized medicine and designer materials


The field of microfluidics has enabled the development of powerful tools for analyzing and manipulating phenomena at the micro- and nano-scales, ranging from chemical analysis of biological samples to controlled synthesis of colloidal materials. In this dissertation we explore four unique platforms for real-time microfluidic measurement, analysis, and control systems with applications at the intersection of biomedicine and materials engineering. First, we show that a real-time biosensor can be used to perform closed-loop control of drug concentrations in the bloodstream of live animals. Second, we show that a commercially available cell-sorting instrument can be used to sort heterogeneous suspensions of synthetic microparticles based on shape using optical scattering measurements, resulting in monodisperse microparticle suspensions with well-defined morphology. Third, we report preliminary results for an image-based cell and microparticle sorter capable of sorting objects using two-dimensional high-speed microscopy and real-time image analysis. Finally, we report a contamination-resistant microfluidic assay for quantitative genetic detection based on real-time loop-mediated isothermal amplification, improving the robustness of point-of-care pathogen detection techniques.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View