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MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization
- Vondrakova, Jana;
- Frolikova, Michaela;
- Ded, Lukas;
- Cerny, Jiri;
- Postlerova, Pavla;
- Palenikova, Veronika;
- Simonik, Ondrej;
- Nahacka, Zuzana;
- Basus, Krystof;
- Valaskova, Eliska;
- Machan, Radek;
- Pacey, Allan;
- Holubcova, Zuzana;
- Koubek, Pavel;
- Ezrova, Zuzana;
- Park, Soojin;
- Liu, Ruiwu;
- Partha, Raghavendran;
- Clark, Nathan;
- Neuzil, Jiri;
- Ikawa, Masahito;
- Erickson, Kent;
- Lam, Kit S;
- Moore, Harry;
- Komrskova, Katerina
- et al.
Published Web Location
https://doi.org/10.1126/sciadv.abn0047Abstract
Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.
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