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Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
- Lo, Min-Tzu;
- Hinds, David A;
- Tung, Joyce Y;
- Franz, Carol;
- Fan, Chun-Chieh;
- Wang, Yunpeng;
- Smeland, Olav B;
- Schork, Andrew;
- Holland, Dominic;
- Kauppi, Karolina;
- Sanyal, Nilotpal;
- Escott-Price, Valentina;
- Smith, Daniel J;
- O'Donovan, Michael;
- Stefansson, Hreinn;
- Bjornsdottir, Gyda;
- Thorgeirsson, Thorgeir E;
- Stefansson, Kari;
- McEvoy, Linda K;
- Dale, Anders M;
- Andreassen, Ole A;
- Chen, Chi-Hua
Published Web Location
https://doi.org/10.1038/ng.3736Abstract
Chi-Hua Chen and colleagues report a GWAS for five personality traits and identify four loci associated with extraversion and two associated with neuroticism at genome-wide significance. They find that the five personality traits are genetically correlated and identify genetic correlations between personality traits and psychiatric disorders.
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