Getting a handle on lipid droplets: Insights into ER-lipid droplet tethering.
- Author(s): Nguyen, Truc B;
- Olzmann, James A
- et al.
Published Web Locationhttps://doi.org/10.1083/jcb.201902160
Lipid droplets (LDs) are hubs for lipid metabolism that form membrane contact sites with multiple organelles. In this issue, Hariri et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201808119) reveal the functions of Mdm1-mediated endoplasmic reticulum (ER)-LD tethering in yeast and Datta et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201808133) identify a role for the Mdm1 orthologue, Snx14, as an ER-LD tether that regulates lipid metabolism in human cells.