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Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1-Ras dependent pathway.

  • Author(s): Lee, Nathanael J
  • Song, Jung Min
  • Cho, Hyun-Ji
  • Sung, You Me
  • Lee, Taehee
  • Chung, Andrew
  • Hong, Sung-Ha
  • Cifelli, Jessica L
  • Rubinshtein, Mark
  • Habib, Lila K
  • Capule, Christina C
  • Turner, R Scott
  • Pak, Daniel TS
  • Yang, Jerry
  • Hoe, Hyang-Sook
  • et al.
Abstract

Our recent study demonstrated that an amyloid-β binding molecule, BTA-EG4, increases dendritic spine number via Ras-mediated signaling. To potentially optimize the potency of the BTA compounds, we synthesized and evaluated an amyloid-β binding analog of BTA-EG4 with increased solubility in aqueous solution, BTA-EG6. We initially examined the effects of BTA-EG6 on dendritic spine formation and found that BTA-EG6-treated primary hippocampal neurons had significantly increased dendritic spine number compared to control treatment. In addition, BTA-EG6 significantly increased the surface level of AMPA receptors. Upon investigation into the molecular mechanism by which BTA-EG6 promotes dendritic spine formation, we found that BTA-EG6 may exert its effects on spinogenesis via RasGRF1-ERK signaling, with potential involvement of other spinogenesis-related proteins such as Cdc42 and CDK5. Taken together, our data suggest that BTA-EG6 boosts spine and synapse number, which may have a beneficial effect of enhancing neuronal and synaptic function in the normal healthy brain.

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