Skip to main content
Open Access Publications from the University of California

UC Irvine

UC Irvine Electronic Theses and Dissertations bannerUC Irvine

Effect of Chirality and Chimeras on Amyloid Aggregation


This thesis reports the activity of macrocyclic β-sheets and their activity against amyloid aggregation. Macrocyclic D-amino acid β-sheets delay or suppress amyloid aggregation at substoichiometric concentrations and show increased activity compared to their L-enantiomers. Fluorescence assays highlight differences between enantiomers and transmission electron microscopy shows the absence of amyloid fibrils in the presence of D-amino acid macrocycles. The diastereomers of the D-amino acid macrocycles are less effective in halting amyloid aggregation. Macrocyclic β-sheet chimeras can suppress or delay amyloid aggregation at stoichiometric amounts. Fluorescence assays show macrocycles containing Aβ-tau hybrid sequences interact with amyloids and delay fibrillization. These studies indicate amyloidogenic peptides are sensitive to chirality and can participate in interactions with chimera peptides.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View