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Open Access Publications from the University of California

High-performance web services for querying gene and variant annotation.


Efficient tools for data management and integration are essential for many aspects of high-throughput biology. In particular, annotations of genes and human genetic variants are commonly used but highly fragmented across many resources. Here, we describe and, high-performance web services for querying gene and variant annotation information. These web services are currently accessed more than three million times permonth. They also demonstrate a generalizable cloud-based model for organizing and querying biological annotation information. and are provided as high-performance web services, accessible at and . Both are offered free of charge to the research community.

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