Skip to main content
eScholarship
Open Access Publications from the University of California

Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: A case study

  • Author(s): Jakubowski, DB
  • Cerussi, AE
  • Bevilacqua, F
  • Shah, N
  • Hsiang, D
  • Butler, J
  • Tromberg, BJ
  • et al.

Published Web Location

https://doi.org/10.1117/1.1629681Creative Commons Attribution 4.0 International Public License
Abstract

Presurgical chemotherapy is widely used in the treatment of locally advanced breast cancer. Monitoring the response to therapy can improve survival and reduce morbidity. We employ a noninvasive, near-infrared method based on diffuse optical spectroscopy (DOS) to quantitatively monitor tumor response to neoadjuvant chemotherapy. DOS was used to monitor tumor response in one patient with locally advanced breast cancer throughout the course of her therapy. Measurements were performed prior to doxorubicin-cyclophosphamide therapy and at several time points over the course of three treatment cycles (68 days). Our results show strong tumor to normal (T/N) tissue contrast in total hemoglobin concentration (T/N =2.4), water fraction (T/N=6.9), tissue hemoglobin oxygen saturation, StO2(T/N=0.9), and lipid fraction (T/N=0.7) prior to treatment. Over a 10-week period, the peak total hemoglobin and water dropped 56 and 67%, respectively. Lipid content nearly returned to baseline (T/ N = 0.9) while StO2exceeded pretreatment levels (T/N = 1.5). Approximately half of the hemoglobin and water changes occurred within 5 days of treatment (26 and 37%, respectively). These data suggest that noninvasive, quantitative optical methods that characterize tumor physiology may be useful in assessing and optimizing individual response to neoadjuvant chemotherapy. © 2004 Society of Photo-Optical Instrumentation Engineers.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View