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Open Access Publications from the University of California

Acoustic radiation force optical coherence elastography using vibro-acoustography

  • Author(s): Qu, Y
  • Ma, T
  • Li, R
  • Qi, W
  • Zhu, J
  • He, Y
  • Shung, KK
  • Zhou, Q
  • Chen, Z
  • et al.

© 2015 SPIE. High-resolution elasticity mapping of tissue biomechanical properties is crucial in early detection of many diseases. We report a method of acoustic radiation force optical coherence elastography (ARF-OCE) based on the methods of vibro-acoustography, which uses a dual-ring ultrasonic transducer in order to excite a highly localized 3-D field. The single element transducer introduced previously in our ARF imaging has low depth resolution because the ARF is difficult to discriminate along the entire ultrasound propagation path. The novel dual-ring approach takes advantage of two overlapping acoustic fields and a few-hundred-Hertz difference in the signal frequencies of the two unmodulated confocal ring transducers in order to confine the acoustic stress field within a smaller volume. This frequency difference is the resulting "beating" frequency of the system. The frequency modulation of the transducers has been validated by comparing the dual ring ARF-OCE measurement to that of the single ring using a homogeneous silicone phantom. We have compared and analyzed the phantom resonance frequency to show the feasibility of our approach. We also show phantom images of the ARF-OCE based vibro-acoustography method and map out its acoustic stress region. We concluded that the dual-ring transducer is able to better localize the excitation to a smaller region to induce a focused force, which allows for highly selective excitation of small regions. The beat-frequency elastography method has great potential to achieve high-resolution elastography for ophthalmology and cardiovascular applications.

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