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Napyradiomycin Derivatives, Produced by a Marine-Derived Actinomycete, Illustrate Cytotoxicity by Induction of Apoptosis
- Farnaes, Lauge;
- Coufal, Nicole G;
- Kauffman, Christopher A;
- Rheingold, Arnold L;
- DiPasquale, Antonio G;
- Jensen, Paul R;
- Fenical, William
Published Web Location
https://doi.org/10.1021/np400466jAbstract
The microbial production, isolation, and structure elucidation of four new napyradiomycin congeners (1-4) is reported. The structures of these compounds, which are new additions to the marine-derived meroterpenoids, were defined by comprehensive spectroscopic analysis and by X-ray crystallography. Using fluorescence-activated cell sorting (FACS) analysis, napyradiomycins 1-4 were observed to induce apoptosis in the colon adenocarcinoma cell line HCT-116, indicating the possibility of a specific biochemical target for this class of cytotoxins.
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