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ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer
- Wang, Junjian;
- Zou, June X;
- Xue, Xiaoqian;
- Cai, Demin;
- Zhang, Yan;
- Duan, Zhijian;
- Xiang, Qiuping;
- Yang, Joy C;
- Louie, Maggie C;
- Borowsky, Alexander D;
- Gao, Allen C;
- Evans, Christopher P;
- Lam, Kit S;
- Xu, Jianzhen;
- Kung, Hsing-Jien;
- Evans, Ronald M;
- Xu, Yong;
- Chen, Hong-Wu
Published Web Location
https://doi.org/10.1038/nm.4070Abstract
ROR-γ antagonists suppress androgen receptor expression and growth of prostate tumors, but not of androgen-responsive healthy tissue, in preclinical models.
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