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Joint profiling of DNA methylation and chromatin architecture in single cells.

  • Author(s): Li, Guoqiang
  • Liu, Yaping
  • Zhang, Yanxiao
  • Kubo, Naoki
  • Yu, Miao
  • Fang, Rongxin
  • Kellis, Manolis
  • Ren, Bing
  • et al.
Abstract

We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues.

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