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Metabolic reprogramming in mutant IDH1 glioma cells
- Pieper, Russell;
- Phillips, Joanna;
- Ronen, Sabrina;
- Izquierdo-Garcia, JL;
- Viswanath, P;
- Eriksson, P;
- Chaumeil, MM;
- Pieper, RO;
- Phillips, JJ;
- Ronen, SM
Published Web Location
http://europepmc.org/articles/PMC4338038?pdf=renderNo data is associated with this publication.
Abstract
© 2015 Izquierdo-Garcia et al.Background: Mutations in isocitrate dehydrogenase (IDH) 1 have been reported in over 70% of low-grade gliomas and secondary glioblastomas. IDH1 is the enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-keto
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