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Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens.

  • Author(s): Santra, Abhishek;
  • Yu, Hai;
  • Tasnima, Nova;
  • Muthana, Musleh M;
  • Li, Yanhong;
  • Zeng, Jie;
  • Kenyond, Nicholas J;
  • Louie, Angelique Y;
  • Chen, Xi
  • et al.
Abstract

O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes. Taking advantage of a bacterial sialyltransferase mutant that can catalyze the transfer of different sialic acid forms from the corresponding sugar nucleotide donors to Lewis x antigens which are fucosylated glycans as well as an efficient one-pot multienzyme (OPME) sialylation system, O-sulfated sialyl Lewis x antigens containing different sialic acid forms and O-sulfation at different locations were systematically synthesized by chemoenzymatic methods.

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